Obesity and NRF2-mediated cytoprotection: Where is the missing link?
Identifieur interne : 000083 ( Main/Exploration ); précédent : 000082; suivant : 000084Obesity and NRF2-mediated cytoprotection: Where is the missing link?
Auteurs : Liliya V. Vasileva [Bulgarie] ; Martina S. Savova [Bulgarie] ; Kristiana M. Amirova [Bulgarie] ; Albena T. Dinkova-Kostova [États-Unis] ; Milen I. Georgiev [Bulgarie]Source :
- Pharmacological research [ 1096-1186 ] ; 2020.
Abstract
The expanding dimensions of the global health crisis of overweight population has defined the term "globesity". Among the most common pathological conditions connected with excessive adiposity are hyperglycemia, insulin resistance, dyslipidemia and hypertension which result in chronic non-communicable diseases (NCD) such as metabolic syndrome (MetS), type 2 diabetes (T2D), and nonalchoholic steatohepatitis (NASH). The contribution of inflammatory-immune reactions in obesity and its related co-morbidities is unequivocal. Increased levels of free fatty acids (FFA), reactive oxygen species (ROS) and reactive nitrogen species (RNS) overloads the homeostatic system resulting in pro-inflammatory adipokines secretion, immune-activation and chronic inflammation in obesity. The cellular mechanisms of defense against oxidative stress are orchestrated by the transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2). Excessive oxidative stress in the cell activates NRF2 which upregulates genes encoding major cytoprotective enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO1), and glutathione S-transferases (GST). The present review aims to clarify the interconnections between chronic inflammation, oxidative overload and NRF2-mediated cytoprotection as potential therapeutic approach in obesity.
DOI: 10.1016/j.phrs.2020.104760
PubMed: 32205234
Affiliations:
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Vasileva</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv</wicri:regionArea><wicri:noRegion>4000 Plovdiv</wicri:noRegion></affiliation></author><author><name sortKey="Savova, Martina S" sort="Savova, Martina S" uniqKey="Savova M" first="Martina S" last="Savova">Martina S. Savova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv</wicri:regionArea><wicri:noRegion>4000 Plovdiv</wicri:noRegion></affiliation></author><author><name sortKey="Amirova, Kristiana M" sort="Amirova, Kristiana M" uniqKey="Amirova K" first="Kristiana M" last="Amirova">Kristiana M. Amirova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv</wicri:regionArea><wicri:noRegion>4000 Plovdiv</wicri:noRegion></affiliation></author><author><name sortKey="Dinkova Kostova, Albena T" sort="Dinkova Kostova, Albena T" uniqKey="Dinkova Kostova A" first="Albena T" last="Dinkova-Kostova">Albena T. Dinkova-Kostova</name><affiliation wicri:level="2"><nlm:affiliation>Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, Scotland, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, Scotland, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Georgiev, Milen I" sort="Georgiev, Milen I" uniqKey="Georgiev M" first="Milen I" last="Georgiev">Milen I. Georgiev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria. Electronic address: milengeorgiev@gbg.bg.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv</wicri:regionArea><wicri:noRegion>4000 Plovdiv</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pharmacological research</title><idno type="eISSN">1096-1186</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The expanding dimensions of the global health crisis of overweight population has defined the term "globesity". Among the most common pathological conditions connected with excessive adiposity are hyperglycemia, insulin resistance, dyslipidemia and hypertension which result in chronic non-communicable diseases (NCD) such as metabolic syndrome (MetS), type 2 diabetes (T2D), and nonalchoholic steatohepatitis (NASH). The contribution of inflammatory-immune reactions in obesity and its related co-morbidities is unequivocal. Increased levels of free fatty acids (FFA), reactive oxygen species (ROS) and reactive nitrogen species (RNS) overloads the homeostatic system resulting in pro-inflammatory adipokines secretion, immune-activation and chronic inflammation in obesity. The cellular mechanisms of defense against oxidative stress are orchestrated by the transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2). Excessive oxidative stress in the cell activates NRF2 which upregulates genes encoding major cytoprotective enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO1), and glutathione S-transferases (GST). The present review aims to clarify the interconnections between chronic inflammation, oxidative overload and NRF2-mediated cytoprotection as potential therapeutic approach in obesity.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32205234</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-1186</ISSN><JournalIssue CitedMedium="Internet"><Volume>156</Volume><PubDate><Year>2020</Year><Month>06</Month></PubDate></JournalIssue><Title>Pharmacological research</Title><ISOAbbreviation>Pharmacol Res</ISOAbbreviation></Journal><ArticleTitle>Obesity and NRF2-mediated cytoprotection: Where is the missing link?</ArticleTitle><Pagination><MedlinePgn>104760</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1043-6618(20)30626-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.phrs.2020.104760</ELocationID><Abstract><AbstractText>The expanding dimensions of the global health crisis of overweight population has defined the term "globesity". Among the most common pathological conditions connected with excessive adiposity are hyperglycemia, insulin resistance, dyslipidemia and hypertension which result in chronic non-communicable diseases (NCD) such as metabolic syndrome (MetS), type 2 diabetes (T2D), and nonalchoholic steatohepatitis (NASH). The contribution of inflammatory-immune reactions in obesity and its related co-morbidities is unequivocal. Increased levels of free fatty acids (FFA), reactive oxygen species (ROS) and reactive nitrogen species (RNS) overloads the homeostatic system resulting in pro-inflammatory adipokines secretion, immune-activation and chronic inflammation in obesity. The cellular mechanisms of defense against oxidative stress are orchestrated by the transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2). Excessive oxidative stress in the cell activates NRF2 which upregulates genes encoding major cytoprotective enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO1), and glutathione S-transferases (GST). The present review aims to clarify the interconnections between chronic inflammation, oxidative overload and NRF2-mediated cytoprotection as potential therapeutic approach in obesity.</AbstractText><CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vasileva</LastName><ForeName>Liliya V</ForeName><Initials>LV</Initials><AffiliationInfo><Affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savova</LastName><ForeName>Martina S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amirova</LastName><ForeName>Kristiana M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dinkova-Kostova</LastName><ForeName>Albena T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, Scotland, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Georgiev</LastName><ForeName>Milen I</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria. Electronic address: milengeorgiev@gbg.bg.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Pharmacol Res</MedlineTA><NlmUniqueID>8907422</NlmUniqueID><ISSNLinking>1043-6618</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Chronic inflammation</Keyword><Keyword MajorTopicYN="Y">KEAP1</Keyword><Keyword MajorTopicYN="Y">Medicinal plants</Keyword><Keyword MajorTopicYN="Y">NRF2</Keyword><Keyword MajorTopicYN="Y">Obesity</Keyword><Keyword MajorTopicYN="Y">Pharmacotherapy</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors declare no competing interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32205234</ArticleId><ArticleId IdType="pii">S1043-6618(20)30626-5</ArticleId><ArticleId IdType="doi">10.1016/j.phrs.2020.104760</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Bulgarie</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Bulgarie"><noRegion><name sortKey="Vasileva, Liliya V" sort="Vasileva, Liliya V" uniqKey="Vasileva L" first="Liliya V" last="Vasileva">Liliya V. Vasileva</name></noRegion><name sortKey="Amirova, Kristiana M" sort="Amirova, Kristiana M" uniqKey="Amirova K" first="Kristiana M" last="Amirova">Kristiana M. Amirova</name><name sortKey="Georgiev, Milen I" sort="Georgiev, Milen I" uniqKey="Georgiev M" first="Milen I" last="Georgiev">Milen I. Georgiev</name><name sortKey="Savova, Martina S" sort="Savova, Martina S" uniqKey="Savova M" first="Martina S" last="Savova">Martina S. Savova</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Dinkova Kostova, Albena T" sort="Dinkova Kostova, Albena T" uniqKey="Dinkova Kostova A" first="Albena T" last="Dinkova-Kostova">Albena T. Dinkova-Kostova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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